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Article

Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia

31 Oct 2024

Abstract excerpt

Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its causality to cachexia by exploring skeletal muscle, whose atrophy strongly associates with poor outcomes. Using multiple mouse models and patient samples, we show that cachectic...

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PMID: 39475511
DOI: 10.1016/j.celrep.2024.114925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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