Article
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.
Cell - 15 Oct 2004
Cai Dongsheng, Frantz J Daniel, Tawa Nicholas E, Melendez Peter A, Oh Byung-Chul, Lidov Hart G W, Hasselgren Per-Olof, Frontera Walter R, Lee Jongsoon, Glass David J, Shoelson Steven E
Abstract excerpt
Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and immobilization. We show that activation of NF-kappaB, through muscle-specific transgenic expression of activated IkappaB kinase beta (MIKK), causes profound muscle wasting that resembles clinical cachexia. In contrast, no overt phenotype was seen upon muscle-specific inhibition of NF-kappaB...
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