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Article

Immunoproteasome subunit PSMB8 promotes skeletal muscle regeneration by regulating macrophage phenotyping switch in mice.

American journal of physiology. Cell physiology - 1 Jun 2025

Zhang Yanhong, Hong Shiyao, Zhang Fan, Yao Kexin, Jin Shuhui, Gao Shijuan, Liu Yan, Li Yulin, Zhang Congcong

Abstract excerpt

Immunoproteasomes regulate the degradation of ubiquitin-coupled proteins and cell differentiation. However, its precise role in skeletal muscle regeneration remains unclear. In this study, we found that expression of the immunoproteasome subunit, PSMB8, increased significantly in young muscles after cardiotoxin-induced injury, whereas its expression was downregulated in injured aged mice. Genetic knockout or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40241316
DOI: 10.1152/ajpcell.00965.2024

Genes

PSMB8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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