Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.

Science signaling - 16 Oct 2012

Enwere Emeka K, Holbrook Janelle, Lejmi-Mrad Rim, Vineham Jennifer, Timusk Kristen, Sivaraj Baktharaman, Isaac Methvin, Uehling David, Al-awar Rima, LaCasse Eric, Korneluk Robert G

Abstract excerpt

The fusion of mononucleated muscle progenitor cells (myoblasts) into multinucleated muscle fibers is a critical aspect of muscle development and regeneration. We identified the noncanonical nuclear factor κB (NF-κB) pathway as a signaling axis that drives the recruitment of myoblasts into new muscle fibers. Loss of cellular inhibitor of apoptosis 1 (cIAP1) protein led to constitutive activation of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bromodeoxyuridine
Share to Inhibitor of Apoptosis Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Skeletal

Share to Muscles

Share to Myoblasts

Share to NF-kappa B

Share to RNA, Small Interfering

Share to Tumor Necrosis Factors

Source

Identifiers

PMID: 23074266
DOI: 10.1126/scisignal.2003086

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.PMID 23074266Read ↗

Suppressing PDGFRβ Signaling Enhances Myocyte Fusion to Promote Skeletal Muscle RegenerationSemantic proximity Read ↗

Tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-kappaB and degradation of MyoD protein.Semantic proximity Read ↗

Myogenesis in dysferlin-deficient myoblasts is inhibited by an intrinsic inflammatory response.Semantic proximity Read ↗

A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis.Semantic proximity Read ↗

TWEAK/Fn14 axis is an important player in fibrosisSemantic proximity Read ↗

Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shorteningSemantic proximity Read ↗

The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscleSemantic proximity Read ↗

The microprotein Minion controls cell fusion and muscle formation.Semantic proximity Read ↗

NF-κB negatively impacts the myogenic potential of muscle-derived stem cells.Semantic proximity Read ↗

Regulation of the Growth of Multinucleated Muscle Cells by an Nfatc2-Dependent PathwaySemantic proximity Read ↗

Impaired activity of the fusogenic micropeptide Myomixer causes myopathy resembling Carey-Fineman-Ziter syndromeSemantic proximity Read ↗

IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.