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Article

Modulation of RhoGTPases improves the behavioral phenotype and reverses astrocytic deficits in a mouse model of Rett syndrome.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2012

De Filippis Bianca, Fabbri Alessia, Simone Daiana, Canese Rossella, Ricceri Laura, Malchiodi-Albedi Fiorella, Laviola Giovanni, Fiorentini Carla

Abstract excerpt

RhoGTPases are crucial molecules in neuronal plasticity and cognition, as confirmed by their role in non-syndromic mental retardation. Activation of brain RhoGTPases by the bacterial cytotoxic necrotizing factor 1 (CNF1) reshapes the actin cytoskeleton and enhances neurotransmission and synaptic plasticity in mouse brains. We evaluated the effects of a single CNF1 intracerebroventricular inoculation in a mouse...

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Identifiers

PMID: 22157810
DOI: 10.1038/npp.2011.301
PMCID: PMC3306877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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