Article
RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome.
Molecular autism - 1 Jan 2017
Pacheco Natasha L, Heaven Michael R, Holt Leanne M, Crossman David K, Boggio Kristin J, Shaffer Scott A, Flint Daniel L, Olsen Michelle L
Abstract excerpt
BACKGROUND: Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 function is derived from transcriptomic studies with the general assumption that alterations in the transcriptome correlate with proteomic changes. Advances in mass spectrometry-based proteomics have facilitated recent interest in the examination...
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