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Article

Mitochondrial free radical overproduction due to respiratory chain impairment in the brain of a mouse model of Rett syndrome: protective effect of CNF1.

Free radical biology & medicine - 1 Jun 2015

De Filippis Bianca, Valenti Daniela, de Bari Lidia, De Rasmo Domenico, Musto Mattia, Fabbri Alessia, Ricceri Laura, Fiorentini Carla, Laviola Giovanni, Vacca Rosa Anna

Abstract excerpt

Rett syndrome (RTT) is a pervasive neurodevelopmental disorder mainly caused by mutations in the X-linked MECP2 gene associated with severe intellectual disability, movement disorders, and autistic-like behaviors. Its pathogenesis remains mostly not understood and no effective therapy is availabl...

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Source

Identifiers

PMID: 25708779
DOI: 10.1016/j.freeradbiomed.2015.02.014

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25708779-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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