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Article

Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas.

BMC medical genetics - 17 Sept 2012

Kiss Nimrod B, Kogner Per, Johnsen John Inge, Martinsson Tommy, Larsson Catharina, Geli Janos

Abstract excerpt

BACKGROUND: In this study we aimed to quantify tumor suppressor gene (TSG) promoter methylation densities levels in primary neuroblastoma tumors and cell lines. A subset of these TSGs is associated with a CpG island methylator phenotype (CIMP) in other tumor types. METHODS: The study panel consisted of 38 primary tumors, 7 established cell lines and 4 healthy references. Promoter methylation was determined by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22984959
DOI: 10.1186/1471-2350-13-83
PMCID: PMC3495052

Genes

CASP8
APC
CDH1
DAPK1
PTEN
RARB
RASSF2

Provenance

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