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Article

Protocadherin PCDH10, involved in tumor progression, is a frequent and early target of promoter hypermethylation in cervical cancer.

Genes, chromosomes & cancer - 1 Nov 2009

Narayan Gopeshwar, Scotto Luigi, Neelakantan Vijayalakshmi, Kottoor Sherine H, Wong Ada Ho Yan, Loke Shee-Loong, Mansukhani Mahesh, Pothuri Bhavana, Wright Jason D, Kaufmann Andreas M, Schneider Achim, Arias-Pulido Hugo, Tao Qian, Murty Vundavalli V

Abstract excerpt

Cervical cancer (CC) is the second most common cancer in women. Currently, no tractable molecular-based therapeutic targets exist for patients with invasive CC and no predictive markers of risk assessment for progression of precancerous lesions are identified. New molecular insights into CC pathogenesis are urgently needed. Towards this goal, we first determined the copy number alterations of chromosome 4 and...

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Source

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Identifiers

PMID: 19681120
DOI: 10.1002/gcc.20703
PMCID: PMC3430375

Genes

PCDH10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protocadherin PCDH10, involved in tumor progression, is a frequent and early target of promoter hypermethylation in cervical cancer.PMID 19681120Read ↗

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Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancerSemantic proximity Read ↗

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Global methylation silencing of clustered <i>proto‐cadherin</i> genes in cervical cancer: serving as diagnostic markers comparable to HPVSemantic proximity Read ↗

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