Article
Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma.
Carcinogenesis - 1 Jul 2012
Shinjo Keiko, Okamoto Yasuyuki, An Byonggu, Yokoyama Toshihiko, Takeuchi Ichiro, Fujii Makiko, Osada Hirotaka, Usami Noriyasu, Hasegawa Yoshinori, Ito Hidemi, Hida Toyoaki, Fujimoto Nobukazu, Kishimoto Takumi, Sekido Yoshitaka, Kondo Yutaka
Abstract excerpt
DNA methylation affects the aggressiveness of human malignancies. Cancers with CpG island methylator phenotype (CIMP), a distinct group with extensive DNA methylation, show characteristic features in several types of tumors. In this study, we initially defined the existence of CIMP in 41 lung adenocarcinomas (AdCas) through genome-wide DNA methylation microarray analysis. DNA methylation status of six CIMP...
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