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BRAF V600E mutation in hairy cell leukemia: from bench to bedside

24 Aug 2016

Abstract excerpt

Hairy cell leukemia (HCL) is a distinct clinicopathological entity whose underlying genetic lesion has remained a mystery for over half a century. The BRAF V600E mutation is now recognized as the causal genetic event of HCL because it is somatic, present in the entire tumor clone, detectable in almost all cases at diagnosis (encompassing the whole disease spectrum), and stable at relapse. BRAF V600E leads to the...

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PMID: 27554081
DOI: 10.1182/blood-2016-07-418434

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