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<scp>BRAF</scp> V600E mutation‐specific antibody, a sensitive diagnostic marker revealing minimal residual disease in hairy cell leukaemia

13 Jul 2013

Abstract excerpt

The proto-oncogene BRAF, found on chromosome 7q34, encodes a serine/threonine kinase that has a regulatory role in the activation of the mitogen-activated protein kinase (MAPK)/ERK signalling cascade, implicated in cancer induction, maintenance and progression (Ascierto et al, 2012). BRAF is one of the most frequently mutated protein kinase genes in human cancer, with the BRAF V600E mutant (a missense...

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Identifiers

PMID: 23848818
DOI: 10.1111/bjh.12429

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