Article
A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy.
Cancer - 15 Jul 2012
Mak Raymond H, Alexander Brian M, Asomaning Kofi, Heist Rebecca S, Liu Chen-yu, Su Li, Zhai Rihong, Ancukiewicz Marek, Napolitano Brian, Niemierko Andrzej, Willers Henning, Choi Noah C, Christiani David C
Abstract excerpt
BACKGROUND: This study examined the association between functional single-nucleotide polymorphisms in candidate genes from oxidative stress pathways and risk of radiation pneumonitis (RP) in patients treated with thoracic radiation therapy for locally advanced lung cancer. METHODS: A review was conducted of 136 patients treated with radiation therapy for lung cancer between 2001 and 2007, and who had prior...
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