Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antigenic drift: Understanding COVID-19.

Immunity - 14 Dec 2021

Yewdell Jonathan W

Abstract excerpt

Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins selected by host adaptive immune systems as the virus circulates in a population. Antigenic drift can substantially limit the duration of immunity conferred by infection and vaccination. Here, I explain the factors contributing to the rapid antigenic drift of the SARS-CoV-2 spike protein and receptor proteins of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity
Share to Biological Evolution
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Mutation

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Share to Vaccination

Source

Open in PubMed Open full text

Identifiers

PMID: 34910934
DOI: 10.1016/j.immuni.2021.11.016
PMCID: PMC8669911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antigenic drift: Understanding COVID-19.PMID 34910934Read ↗

Mapping the antigenic diversification of SARS-CoV-2Semantic proximity Read ↗

Rapidly Evolving SARS-CoV-2: A Brief Review Regarding the Variants and their Effects on Vaccine Efficacies.Semantic proximity Read ↗

Memory Gaps in America: Mutational and Immunoinformatic Analysis of Evolving SARS-CoV-2 Variants of Concern and Interest.Semantic proximity Read ↗

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variantsSemantic proximity Read ↗

Antigenic evolution of SARS coronavirus 2Semantic proximity Read ↗

Preliminary Immunogenicity of a Pan-COVID-19 T Cell Vaccine in HLA-A*02:01 MiceSemantic proximity Read ↗

The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 EvolutionSemantic proximity Read ↗

Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spikeSemantic proximity Read ↗

Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody TreatmentSemantic proximity Read ↗

Viral population genomics reveals host and infectivity impact on SARS-CoV-2 adaptive landscapeSemantic proximity Read ↗

The evolutionary dynamics of receptor binding avidity in influenza A: a mathematical model for a new antigenic drift hypothesis.Semantic proximity Read ↗

Antibody escape, the risk of serotype formation, and rapid immune waning: modeling the implications of SARS-CoV-2 immune evasionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.