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Article

PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.

Diabetes - 1 Nov 2008

Ma Lijun, Hanson Robert L, Que Lorem N, Guo Yan, Kobes Sayuko, Bogardus Clifton, Baier Leslie J

Abstract excerpt

OBJECTIVE: A prior genome-wide association (GWA) study in Pima Indians identified variants within PCLO that were associated with early-onset type 2 diabetes. PCLO encodes a presynaptic cytomatrix protein that functions as a Ca(2+) sensor that may be involved in insulin secretion and/or insulin action. Therefore, PCLO was analyzed as a candidate gene for type 2 diabetes. RESEARCH DESIGN AND METHODS: Sequencing of...

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Source

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Identifiers

PMID: 18647954
DOI: 10.2337/db07-1800
PMCID: PMC2570415

Genes

PCLO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.PMID 18647954Read ↗

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