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Article

Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.

PloS one - 1 Jan 2011

Brault Véronique, Martin Benoît, Costet Nathalie, Bizot Jean-Charles, Hérault Yann

Abstract excerpt

Down syndrome (DS) is a complex genetic syndrome characterized by intellectual disability, dysmorphism and variable additional physiological traits. Current research progress has begun to decipher the neural mechanisms underlying cognitive impairment, leading to new therapeutic perspectives. Pentylenetetrazol (PTZ) has recently been found to have positive effects on learning and memory capacities of a DS mouse...

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Source

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Identifiers

PMID: 22140471
DOI: 10.1371/journal.pone.0027845
PMCID: PMC3227573

Genes

CSTB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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