Article

Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy21 human cellular and mouse models

2024-04-14

Abstract excerpt

Down syndrome, resulting from trisomy of human chromosome 21, is a common form of chromosomal disorder that results in intellectual disability and altered risk of several medical conditions. Individuals with Down syndrome have a greatly increased risk of Alzheimer’s disease (DSAD), due to the presence of the APP gene on chromosome 21 that encodes the amyloid-β precursor protein (APP). APP can be processed to gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1c135e6-a6ce-5a8e-8486-fc182a0deaf7
DOI: 10.1101/2024.04.10.588836

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy21 human cellular and mouse modelsDOI 10.1101/2024.04.10.588836Read

Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease – Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin BSemantic proximity Read

Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin BSemantic proximity Read

The effects of <i>CSTB</i> duplication on APP/amyloid-β pathology and cathepsin activity in a mouse modelSemantic proximity Read

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APPSemantic proximity Read

<i>β</i>-Secretases, Alzheimer’s Disease, and Down SyndromeSemantic proximity Read

Genetic mapping of APP and amyloid-β biology modulation by trisomy 21Semantic proximity Read

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brainSemantic proximity Read

Alzheimer‐like pathology in trisomy 21 cerebral organoids amenable to pharmacological inhibition reveals BACE2 as a gene‐dose‐sensitive AD‐suppressor in human brainSemantic proximity Read

Trisomy 21 and the BrainSemantic proximity Read

Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndromeSemantic proximity Read

“Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain”Semantic proximity Read

Loss of Proteostasis and Abnormal Aging in Down Syndrome: From Mechanisms to InterventionsSemantic proximity Read