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Article

Brain phenotype of transgenic mice overexpressing cystathionine β-synthase.

PloS one - 1 Jan 2012

Régnier Vinciane, Billard Jean-Marie, Gupta Sapna, Potier Brigitte, Woerner Stéphanie, Paly Evelyne, Ledru Aurélie, David Sabrina, Luilier Sabrina, Bizot Jean-Charles, Vacano Guido, Kraus Jan P, Patterson David, Kruger Warren D, Delabar Jean M, London Jaqueline

Abstract excerpt

BACKGROUND: The cystathionine β-synthase (CBS) gene, located on human chromosome 21q22.3, is a good candidate for playing a role in the Down Syndrome (DS) cognitive profile: it is overexpressed in the brain of individuals with DS, and it encodes a key enzyme of sulfur-containing amino acid (SAA) metabolism, a pathway important for several brain physiological processes. METHODOLOGY/PRINCIPAL FINDINGS: Here, we...

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Identifiers

PMID: 22253703
DOI: 10.1371/journal.pone.0029056
PMCID: PMC3257219

Genes

CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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