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Article

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK‐801

24 Jul 2008

Abstract excerpt

Down syndrome (DS), caused by trisomy of human chromosome 21 (chr21), is the most common genetic cause of intellectual disability. The Ts65Dn mouse model of DS is trisomic for orthologs of 94 chr21-encoded, confirmed protein-coding genes and displays a number of behavioral deficits. Recently, Ts65Dn mice were shown to be hypersensitive to the locomotor stimulatory effects of the high-affinity N-methyl-d-aspartate...

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PMID: 19125866
DOI: 10.1111/j.1601-183x.2008.00428.x

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