Article

The effects of <i>CSTB</i> duplication on APP/amyloid-β pathology and cathepsin activity in a mouse model

2020-10-30

Abstract excerpt

People with Down syndrome (DS), caused by trisomy of chromosome 21 have a greatly increased risk of developing Alzheimer’s disease (AD). This is in part because of triplication of a chromosome 21 gene, APP . This gene encodes amyloid precursor protein, which is cleaved to form amyloid-β that accumulates in the brains of people who have AD. Recent experimental results demonstrate that a gene or genes on chromosome...

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Literature Corpus work: 5cb447e1-1d1b-54a2-a783-f530e5c9a373
DOI: 10.1101/2020.10.30.362004

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