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Article

Molecular determinants of HIV-2 R5-X4 tropism in the V3 loop: development of a new genotypic tool.

The Journal of infectious diseases - 1 Jan 2012

Visseaux Benoit, Hurtado-Nedelec Margarita, Charpentier Charlotte, Collin Gilles, Storto Alexandre, Matheron Sophie, Larrouy Lucile, Damond Florence, Brun-Vézinet Françoise, Descamps Diane

Abstract excerpt

OBJECTIVE: The use of CCR5 inhibitors requires a tool to predict human immunodeficiency virus type 2 (HIV-2) tropism, as established in HIV-1. The aim of our study was to identify genotypic determinants of HIV-2 tropism located in the gp105 V3 loop. METHODS: HIV-2 tropism phenotypic assays were performed on 53 HIV-2 clinical isolates using GFP expressing human osteosarcoma T4 [GHOST(3)] cell lines expressing CD4...

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Share to Cell Line, Tumor
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genotyping Techniques

Share to RNA, Viral

Share to Sequence Analysis, RNA

Share to Viral Tropism

Source

Identifiers

PMID: 22140264
DOI: 10.1093/infdis/jir698

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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