Article
V3 net charge: additional tool in HIV-1 tropism prediction.
AIDS research and human retroviruses - 1 Dec 2014
Montagna Claudia, De Crignis Elisa, Bon Isabella, Re Maria Carla, Mezzaroma Ivano, Turriziani Ombretta, Graziosi Cecilia, Antonelli Guido
Abstract excerpt
Genotype-based algorithms are valuable tools for the identification of patients eligible for CCR5 inhibitors administration in clinical practice. Among the available methods, geno2pheno[coreceptor] (G2P) is the most used online tool for tropism prediction. This study was conceived to assess if the combination of G2P prediction with V3 peptide net charge (NC) value could improve the accuracy of tropism prediction....
Topics
- CCR5 Receptor Antagonists
- Genotype
- HIV Envelope Protein gp120
- HIV Fusion Inhibitors
- HIV Infections
- HIV-1
- Humans
- Nucleic Acid Amplification Techniques
- Peptide Fragments
- Predictive Value of Tests