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Article

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.

Nature genetics - 1 Dec 2010

Galarneau Geneviève, Palmer Cameron D, Sankaran Vijay G, Orkin Stuart H, Hirschhorn Joel N, Lettre Guillaume

Abstract excerpt

We used resequencing and genotyping in African Americans with sickle cell anemia (SCA) to characterize associations with fetal hemoglobin (HbF) levels at the BCL11A, HBS1L-MYB and β-globin loci. Fine-mapping of HbF association signals at these loci confirmed seven SNPs with independent effects and increased the explained heritable variation in HbF levels from 38.6% to 49.5%. We also identified rare missense...

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Identifiers

PMID: 21057501
DOI: 10.1038/ng.707
PMCID: PMC3740938

Genes

MYB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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