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Article

G2E3 is a dual function ubiquitin ligase required for early embryonic development.

The Journal of biological chemistry - 8 Aug 2008

Brooks William S, Helton E Scott, Banerjee Sami, Venable Melanie, Johnson Larry, Schoeb Trenton R, Kesterson Robert A, Crawford David F

Abstract excerpt

G2E3 is a putative ubiquitin ligase (E3) identified in a microarray screen for mitotic regulatory proteins. It shuttles between the cytoplasm and nucleus, concentrating in nucleoli and relocalizing to the nucleoplasm in response to DNA damage. In this study, we demonstrate that G2E3 is an unusual ubiquitin ligase that is essential in early embryonic development to prevent apoptotic death. This protein has a...

Topics

Amino Acid Sequence
Animals
Apoptosis
Central Nervous System
Embryonic Development
Gene Expression Regulation, Developmental
Gene Expression Regulation, Enzymologic
Genotype
Mice
Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Sequence Alignment

Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 18511420
DOI: 10.1074/jbc.M803238200
PMCID: PMC2494922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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