Article
Generation and characterization of a Gdf1 conditional null allele.
Genesis (New York, N.Y. : 2000) - 1 Jul 2008
Bengtsson Henrik, Epifantseva Irina, Abrink Magnus, Kylberg Annika, Kullander Klas, Ebendal Ted, Usoskin Dmitry
Abstract excerpt
Growth differentiation factor-1 (GDF1), a TGF-beta superfamily member, participates in early embryo patterning. Later functions are implied by the Gdf1 expression in the peripheral and central nervous system. Such roles of the gene have been difficult to study, because Gdf1 null mice die during late embryogenesis. Here, we report the production of a mouse carrying a conditional Gdf1 allele, with exon 2 flanked by...
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