Article
Normal mitral cell dendritic development in the setting of Mecp2 mutation.
Neuroscience - 27 Jan 2012
Palmer A M, Degano A L, Park M J, Ramamurthy S, Ronnett G V
Abstract excerpt
Rett syndrome (RTT) is an autism spectrum disorder caused by mutation in the gene encoding methyl CpG binding protein 2 (MECP2). Evidence to date suggests that these disorders display defects in synaptic organization and plasticity. A hallmark of the pathology in RTT has been identified as decreased dendritic arborization, which has been interpreted to represent abnormal dendritic formation and pruning during...
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