Article
Expression of MeCP2 in olfactory receptor neurons is developmentally regulated and occurs before synaptogenesis.
Molecular and cellular neurosciences - 1 Apr 2003
Cohen Deborah R S, Matarazzo Valéry, Palmer Amy M, Tu Yajun, Jeon Ok-Hee, Pevsner Jonathan, Ronnett Gabriele V
Abstract excerpt
Rett syndrome, a neurodevelopmental disorder hypothesized to be due to defective neuronal maturation, is a result of mutations in the mecp2 gene encoding the transcriptional repressor methyl-CpG binding protein (MeCP2). We utilized the olfactory system, which displays postnatal neurogenesis, as a model to investigate MeCP2 expression during development and after injury. MeCP2 expression increased postnatally,...
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