Article
MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons.
Experimental neurology - 1 Mar 2010
Kishi Noriyuki, Macklis Jeffrey D
Abstract excerpt
Rett syndrome is a human neurodevelopmental disorder presenting almost exclusively in female infants; it is the second most common cause of mental retardation in girls, after Down's syndrome. The identification in 1999 that mutation of the methyl-CpG-binding protein 2 (MECP2) gene on the X chromosome causes Rett syndrome has led to a rapid increase in understanding of the neurobiological basis of the disorder....
Topics
- Animals
- Animals, Newborn
- Cell Differentiation
- Cell Growth Processes
- Cell Transplantation
- Cerebral Cortex
- Dendrites
- Embryo, Mammalian
- Embryonic Stem Cells
- Female
- Green Fluorescent Proteins