Article
MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively.
Molecular and cellular neurosciences - 1 Apr 2008
Palmer Amy, Qayumi Jibran, Ronnett Gabriele
Abstract excerpt
Over 200 mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2) are known to cause Rett syndrome (RTT), a multiphasic neurodevelopmental disorder that results in motor and cognitive impairments; however, little is known about the neurobiology of RTT. Here, we employ the MeCP2(308/y) mouse model of RTT to investigate the course of the neuronal defects imparted by MeCP2 mutation. Using the olfactory...
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