Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration.

Ophthalmology - 1 Feb 2012

Smailhodzic Dzenita, Klaver Caroline C W, Klevering B Jeroen, Boon Camiel J F, Groenewoud Joannes M M, Kirchhof Bernd, Daha Mohamed R, den Hollander Anneke I, Hoyng Carel B

Abstract excerpt

PURPOSE: Systemic complement activation is associated with age-related macular degeneration (AMD) and has mainly been attributed to a risk allele in the complement factor H (CFH) gene. Whether other important AMD genes also influence complement activation is unclear. In the present case-control study, complement activity and concentrations of complement components and their activation products are measured in AMD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Complement Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement C3

Share to Complement Factor B

Share to Complement Factor H

Share to Complement Factor I

Share to Macular Degeneration

Share to Proteins

Source

Identifiers

PMID: 22133792
DOI: 10.1016/j.ophtha.2011.07.056

Genes

CFH
ARMS2
CFB
CFI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration.PMID 22133792Read ↗

Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.Semantic proximity Read ↗

Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.Semantic proximity Read ↗

Systemic complement activation in age-related macular degeneration.Semantic proximity Read ↗

Analysis of Risk Alleles and Complement Activation Levels in Familial and Non-Familial Age-Related Macular Degeneration.Semantic proximity Read ↗

Complement Activation Levels Are Related to Disease Stage in AMD.Semantic proximity Read ↗

C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes.Semantic proximity Read ↗

Genetic control of the alternative pathway of complement in humans and age-related macular degeneration.Semantic proximity Read ↗

Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular DegenerationSemantic proximity Read ↗

A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo.Semantic proximity Read ↗

Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population.Semantic proximity Read ↗

CFH haplotypes and ARMS2, C2, C3, and CFB alleles show association with susceptibility to age-related macular degeneration in Mexicans.Semantic proximity Read ↗

Systemic complement levels in patients with age-related macular degeneration carrying rare or low-frequency variants in the CFH gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.