Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systemic complement activation in age-related macular degeneration.

PloS one - 2 Jul 2008

Scholl Hendrik P N, Charbel Issa Peter, Walier Maja, Janzer Stefanie, Pollok-Kopp Beatrix, Börncke Florian, Fritsche Lars G, Chong Ngaihang V, Fimmers Rolf, Wienker Thomas, Holz Frank G, Weber Bernhard H F, Oppermann Martin

Abstract excerpt

Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of complement activation underlies AMD, parameters of complement activation in blood plasma were determined together with disease-associated genetic markers in AMD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Complement Activation

Share to Complement Factor H

Share to Genetic Variation

Share to Macular Degeneration

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 18596911
DOI: 10.1371/journal.pone.0002593
PMCID: PMC2440421

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systemic complement activation in age-related macular degeneration.PMID 18596911Read ↗

Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration.Semantic proximity Read ↗

Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration.Semantic proximity Read ↗

Genetic control of the alternative pathway of complement in humans and age-related macular degeneration.Semantic proximity Read ↗

Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.Semantic proximity Read ↗

The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application.Semantic proximity Read ↗

Complement Activation Levels Are Related to Disease Stage in AMD.Semantic proximity Read ↗

Age-related macular degeneration: Complement in action.Semantic proximity Read ↗

Systemic complement levels in patients with age-related macular degeneration carrying rare or low-frequency variants in the CFH gene.Semantic proximity Read ↗

The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.Semantic proximity Read ↗

The complement system in age-related macular degeneration.Semantic proximity Read ↗

Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.Semantic proximity Read ↗

Age‐related macular degeneration: A disease of extracellular complement amplificationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.