Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.

Investigative ophthalmology & visual science - 1 Dec 2009

Reynolds Robyn, Hartnett M Elizabeth, Atkinson John P, Giclas Patricia C, Rosner Bernard, Seddon Johanna M

Abstract excerpt

PURPOSE: Several genes encoding complement system components and fragments are associated with age-related macular degeneration (AMD). This study was conducted to determine whether alterations in circulating levels of these markers of complement activation and regulation are also independently associated with advanced AMD and whether they are related to AMD genotypes. METHODS: Plasma and DNA samples were selected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement C2
Share to Complement C3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Factor B

Share to Complement Factor H

Share to Complement Factor I

Share to Complement Pathway, Alternative

Share to Complement System Proteins

Share to Macular Degeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 19661236
DOI: 10.1167/iovs.09-3928
PMCID: PMC2826794

Genes

CFH
CFB
ARMS2
CFI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.PMID 19661236Read ↗

Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration.Semantic proximity Read ↗

Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.Semantic proximity Read ↗

Complement Activation Levels Are Related to Disease Stage in AMD.Semantic proximity Read ↗

Analysis of Risk Alleles and Complement Activation Levels in Familial and Non-Familial Age-Related Macular Degeneration.Semantic proximity Read ↗

Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular DegenerationSemantic proximity Read ↗

The molecular genetic basis of age-related macular degeneration: an overview.Semantic proximity Read ↗

Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.Semantic proximity Read ↗

Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration.Semantic proximity Read ↗

Systemic complement activation in age-related macular degeneration.Semantic proximity Read ↗

Complement factor B polymorphism and the phenotype of early age-related macular degeneration.Semantic proximity Read ↗

The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application.Semantic proximity Read ↗

Genetic analysis of age-related macular degeneration highlights precision therapy opportunities for patients with high polygenic riskSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.