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Article

A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo.

Scientific reports - 31 May 2016

Paun Constantin C, Lechanteur Yara T E, Groenewoud Joannes M M, Altay Lebriz, Schick Tina, Daha Mohamed R, Fauser Sascha, Hoyng Carel B, den Hollander Anneke I, de Jong Eiko K

Abstract excerpt

The complement system is the first line of defense against foreign intruders, and deregulation of this system has been described in multiple diseases. In age-related macular degeneration (AMD), patients have higher complement activation levels compared to controls. Recently, a combination of three single nucleotide polymorphisms (SNPs) in genes of the complement system, referred to as a complotype, has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27241480
DOI: 10.1038/srep26568
PMCID: PMC4886525

Genes

CFB
CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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