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Article

Genetic control of the alternative pathway of complement in humans and age-related macular degeneration.

Human molecular genetics - 1 Jan 2010

Hecker Laura A, Edwards Albert O, Ryu Euijung, Tosakulwong Nirubol, Baratz Keith H, Brown William L, Charbel Issa Peter, Scholl Hendrik P, Pollok-Kopp Beatrix, Schmid-Kubista Katharina E, Bailey Kent R, Oppermann Martin

Abstract excerpt

Activation of the alternative pathway of complement is implicated in common neurodegenerative diseases including age-related macular degeneration (AMD). We explored the impact of common variation in genes encoding proteins of the alternative pathway on complement activation in human blood and in AMD. Genetic variation across the genes encoding complement factor H (CFH), factor B (CFB) and component 3 (C3) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19825847
DOI: 10.1093/hmg/ddp472
PMCID: PMC2792151

Genes

CFH
CFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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