Article
Analysis of Risk Alleles and Complement Activation Levels in Familial and Non-Familial Age-Related Macular Degeneration.
PloS one - 1 Jan 2016
Saksens Nicole T M, Lechanteur Yara T E, Verbakel Sanne K, Groenewoud Joannes M M, Daha Mohamed R, Schick Tina, Fauser Sascha, Boon Camiel J F, Hoyng Carel B, den Hollander Anneke I
Abstract excerpt
AIMS: Age-related macular degeneration (AMD) is a multifactorial disease, in which complement-mediated inflammation plays a pivotal role. A positive family history is an important risk factor for developing AMD. Certain lifestyle factors are shown to be significantly associated with AMD in non-familial cases, but not in familial cases. This study aimed to investigate whether the contribution of common genetic...
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