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Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.

Ophthalmology - 1 Jul 2018

Lorés-Motta Laura, Paun Constantin C, Corominas Jordi, Pauper Marc, Geerlings Maartje J, Altay Lebriz, Schick Tina, Daha Mohamed R, Fauser Sascha, Hoyng Carel B, den Hollander Anneke I, de Jong Eiko K

Abstract excerpt

PURPOSE: To identify genetic variants associated with complement activation, which may help to select age-related macular degeneration (AMD) patients for complement-inhibiting therapies. DESIGN: Genome-wide association study (GWAS) followed by replication and meta-analysis. PARTICIPANTS: AMD patients and controls (n = 2245). METHODS: A GWAS on serum C3d-to-C3 ratio was performed in 1548 AMD patients and controls....

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Share to Apolipoproteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29398083
DOI: 10.1016/j.ophtha.2017.12.023

Genes

CFH
CFHR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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