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Article

Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells

30 Apr 2018

Abstract excerpt

Abstract Programmed death ligand 1 (PD-L1)-mediated induction of immune tolerance has been vigorously investigated in autoimmunity and anti-tumor immunity. However, details of the mechanism by which PD-L1 is induced in CD4+ T cells are unknown. Here, we revealed the potential function of Klf1 and Egr2-mediated induction of PD-L1 in CD4+ T cells. We focused on the molecules specifically expressed in CD4+CD25−LAG3+...

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PMID: 29728568
DOI: 10.1038/s41598-018-25302-1

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