Article
Allelic variant of NOS1AP effects on cardiac alternans of repolarization during exercise testing.
Scandinavian journal of clinical and laboratory investigation - 1 Apr 2012
Koskela Jenni, Kähönen Mika, Nieminen Tuomo, Lehtinen Rami, Viik Jari, Nikus Kjell, Niemelä Kari, Kööbi Tiit, Tobin Martin D, Samani Nilesh J, Turjanmaa Väinö, Pörsti Ilkka, Lehtimäki Terho
Abstract excerpt
INTRODUCTION: A repolarization abnormality manifested as T-wave alternans (TWA) in electrocardiogram (ECG) predicts cardiovascular mortality. A common variant in the NOS1AP gene is associated with mortality and QT interval duration, possibly in a gender-specific manner, but data is lacking on potential association with TWA. This study tested association between rs10494366 in NOS1AP and both TWA and 4-year...
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