Article
Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study.
Translational research : the journal of laboratory and clinical medicine - 1 Aug 2008
Koskela Jenni, Kähönen Mika, Fan Meng, Nieminen Tuomo, Lehtinen Rami, Viik Jari, Nikus Kjell, Niemelä Kari, Kööbi Tiit, Turjanmaa Väinö, Pörsti Ilkka, Lehtimäki Terho
Abstract excerpt
T-wave alternans (TWA) in electrocardiography (ECG) is a marker of cardiac repolarization, the molecular regulation of which is incompletely understood. High TWA and prolonged QT intervals are both associated with ventricular arrhythmias and sudden death. Therefore, we tested the hypothesis of whether the same mutations that influence the QT interval also affect TWA variation. We examined the effect of 3 ion...
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