Article
MTHFR polymorphisms and risk of chronic lymphocytic leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2004
Rudd Matthew F, Sellick Gabrielle S, Allinson Ruth, Matutes Estella, Catovsky Daniel, Houlston Richard S
Abstract excerpt
Folate availability is critical for DNA integrity, required for the transfer of methyl groups in the biosynthesis of thymidilate. Reduction of 5,10-methylenetetrahydrofolate, a donor for methylating dUMP to dTMP in DNA synthesis, to 5-methyltetrahydrofolate, the primary methyl donor for methionine synthesis, is catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR). The MTHFR polymorphisms C677T and A1298C...
Topics
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Odds Ratio