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Article

Rapid detection and further characterization of infection with hepatitis B virus variants containing a stop codon in the distal pre-C region.

The Journal of general virology - 1 Sept 1990

Li J, Tong S, Vitvitski L, Zoulim F, Trépo C

Abstract excerpt

Recently, hepatitis B virus (HBV) replication in the absence of HBe antigenaemia has been attributed to HBV variants with a TAG stop codon in the distal pre-C region associated with one or two point mutations. We describe here a rapid detection method for the diagnosis of such HBeAg-negative HBV variants using selective oligonucleotide hybridization. The entire pre-C region was amplified by the polymerase chain...

Topics

Base Sequence
Codon
DNA, Viral
Genetic Variation
Hepatitis B
Hepatitis B e Antigens
Hepatitis B virus
Humans
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Polymerase Chain Reaction

Source

Identifiers

PMID: 2212990
DOI: 10.1099/0022-1317-71-9-1993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2212990-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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