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Article

Mutations in the pre-core region of hepatitis B virus DNA in patients with chronic liver diseases.

Yonsei medical journal - 1 Jun 1993

Kim W H, Kim K H, Chung J P, Kang J K, Park I S

Abstract excerpt

To investigate the prevalence of point mutation in the pre-core (pre-C) region of hepatitis B virus (HBV) DNA, we performed dot blot hybridization and sequencing of enzymatically amplified HBV DNA from the sera of 25 patients with HBeAg-positive and 32 patients with HBeAg-negative chronic liver diseases. The pre-C region of HBV DNA was successfully amplified by polymerase chain reaction (PCR) from 55 (96.5%) of...

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Identifiers

PMID: 8379195
DOI: 10.3349/ymj.1993.34.2.158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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