Article
Direct detection of HBV preC mutants in heterogeneous viral populations by a modified DNA sequencing method.
Research in virology - 1 Jan 2000
Manzin A, Paolucci S, Lampertico P, Menzo S, Rumi M G, Colombo M, Clementi M
Abstract excerpt
A modified method for the direct sequencing of double-stranded DNA products of PCR amplification is described and has been applied to the analysis of hepatitis B virus (HBV) preC/C region in samples from persistently infected patients with chronic hepatitis. Data was obtained from both hepatitis...
Topics
- Base Sequence
- Chronic Disease
- Genetic Variation
- Hepatitis B
- Hepatitis B Core Antigens
- Hepatitis B virus
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Precursors
- Sequence Analysis, DNA