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Article

Direct detection of HBV preC mutants in heterogeneous viral populations by a modified DNA sequencing method.

Research in virology - 1 Jan 2000

Manzin A, Paolucci S, Lampertico P, Menzo S, Rumi M G, Colombo M, Clementi M

Abstract excerpt

A modified method for the direct sequencing of double-stranded DNA products of PCR amplification is described and has been applied to the analysis of hepatitis B virus (HBV) preC/C region in samples from persistently infected patients with chronic hepatitis. Data was obtained from both hepatitis B e antigen (HBeAg)-positive and -negative chronic carriers. A high prevalence of mixed viral populations (wild-type...

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Identifiers

PMID: 8210713
DOI: 10.1016/s0923-2516(06)80045-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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