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Article

In vitro replication competence of a cloned hepatitis B virus variant with a nonsense mutation in the distal pre-C region.

Virology - 1 Apr 1991

Tong S P, Diot C, Gripon P, Li J, Vitvitski L, Trépo C, Guguen-Guillouzo C

Abstract excerpt

Hepatitis B virus (HBV) variants with a nonsense mutation in the distal pre-C region have been detected in patients positive for anti-HBe, and the complete nucleotide sequence of one cloned pre-C variant has been determined. Transfection of this HBV variant clone into the human hepatoma cell line HepG2 resulted in the appearance of major HBV transcripts, replicative forms of viral DNA evidenced by both molecular...

Topics

DNA Replication
DNA, Viral
DNA-Directed DNA Polymerase
Hepatitis B Core Antigens
Hepatitis B Surface Antigens
Hepatitis B e Antigens
Hepatitis B virus
Humans
Mutation
Transfection
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

Source

Identifiers

PMID: 2014646
DOI: 10.1016/0042-6822(91)90908-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2014646-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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