Selection for a pre-C stop codon mutation in a hepatitis B virus variant with a pre-C initiation codon mutation during interferon treatment.

doi:10.1016/0168-8278(91)90083-n

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Article

Selection for a pre-C stop codon mutation in a hepatitis B virus variant with a pre-C initiation codon mutation during interferon treatment.

Journal of hepatology - 1 Nov 1991

Santantonio T, Jung M C, Schneider R, Pastore G, Pape G R, Will H

Abstract excerpt

Hepatitis B virus (HBV) variants with a stop codon, a mutated translation initiation codon or other mutations in the pre-C region which prevent e-antigen expression are highly prevalent in anti-HBe chronic carriers and can be positively selected from a mixed virus infection. Our laboratories rece...

Topics

Adult
Base Sequence
Carrier State
Codon
DNA, Viral
Follow-Up Studies
Genetic Variation
Hepatitis B
Hepatitis B virus
Humans
Interferons
Male
Molecular Sequence Data
Mutagenesis
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 1725530
DOI: 10.1016/0168-8278(91)90083-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1725530-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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