Article
Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation.
Oncogene - 6 Jan 2000
Nakajima H, Nakajima H O, Soonpaa M H, Jing S, Field L J
Abstract excerpt
Thymoma is the most common tumor of the anterior-superior mediastinum. We have identified a line of transgenic mice which spontaneously and heritably develop thymomas at a very high penetrance. The available data suggest that thymoma formation in these mice results as a consequence of transgene insertional mutagenesis. Immune histologic analyses indicate that the thymomas are of epithelial cell origin. Survival...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.