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Article

TM1 and TM2: two mutant alleles that are involved in the pre-TCR/TCR signaling.

Immunology and cell biology - 1 Jul 2008

Huang Fang, Naramura Mayumi, Gu Hua

Abstract excerpt

It has been shown that the transgene insertional mutations TM1 and TM2 constitute a genetic trait controlling thymocyte development. Here we conducted a detailed analysis of the impact of TM1 and TM2 double mutation on thymocyte development. We found that the hemizygous TM1 and TM2 double transgenic mice possessed much smaller thymi. Flow cytometric analysis revealed a severe blockage of T-cell development at the...

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Identifiers

PMID: 18392045
DOI: 10.1038/icb.2008.11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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