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Article

Does rosiglitazone affect adiposity and cardiac function in genetic diabetic mice?

European journal of pharmacology - 30 Jan 2013

Hemmeryckx Bianca, Hoylaerts Marc F, Gallacher David J, Rong Lu Hua, Himmelreich Uwe, D'hooge Jan, Swinnen Melissa, Lijnen Henri R

Abstract excerpt

Rosiglitazone ((RS)-5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione, RGZ)-induced adverse drug effects in diabetic patients were not adequately predicted by current preclinical rodent models. Therefore, we have used the Akita mouse with genetic predisposition to diabetes to unravel the underlying molecular mechanisms. The effect of RGZ on adipose tissue and on cardiac function was...

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Identifiers

PMID: 23228931
DOI: 10.1016/j.ejphar.2012.11.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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