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Article

Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations.

The Journal of general physiology - 1 Dec 2011

Pan Albert C, Cuello Luis G, Perozo Eduardo, Roux Benoît

Abstract excerpt

The amount of ionic current flowing through K(+) channels is determined by the interplay between two separate time-dependent processes: activation and inactivation gating. Activation is concerned with the stimulus-dependent opening of the main intracellular gate, whereas inactivation is a spontaneous conformational transition of the selectivity filter toward a nonconductive state occurring on a variety of...

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Identifiers

PMID: 22124115
DOI: 10.1085/jgp.201110670
PMCID: PMC3226968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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