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Article

Serum progranulin levels in patients with frontotemporal lobar degeneration and Alzheimer's disease: detection of GRN mutations in a Spanish cohort.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Antonell Anna, Gil Silvia, Sánchez-Valle Raquel, Balasa Mircea, Bosch Beatriz, Prat Ma Carmen, Chiollaz Anne-Cécile, Fernández Manel, Yagüe Jordi, Molinuevo José Luis, Lladó Albert

Abstract excerpt

Progranulin gene (GRN) mutations cause frontotemporal lobar degeneration (FTLD) with TDP43-positive inclusions, although its clinical phenotype is heterogeneous and includes patients classified as behavioral variant-FTLD (bvFTLD), progressive non-fluent aphasia (PNFA), corticobasal syndrome, Alzheimer's disease (AD), or Parkinson's disease (PD). Our main objective was to study if low serum progranulin protein...

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Source

Identifiers

PMID: 22647257
DOI: 10.3233/JAD-2012-112120

Genes

GRN
PRNP
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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